Endocrine Abstracts

Aims/Introduction: To evaluate the impact of diabetes mellitus on the incidence of related micro- and macrovascular outcomes as well as cost analysis in people with type 2 diabetes mellitus.Materials and methods: In a cohort study, registered patients with type 2 diabetes mellitus were followed for 10 years at a tertiary care center. The type of medications and clinical data were extracted from patients’ archives. Incidence of mortality, micro- and ...

The causative link between circulating glucocorticoid excess and osteoporosis is established. Although circulating cortisol levels do not change significantly with age, local tissue metabolism may be implicated in age-related bone loss. The enzyme11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) increases local cortisol production, is expressed in human osteoblasts and its activity increases with age leading to a decrease in bone formation. We hypothesised that sele...

Background: Immune checkpoint inhibitors, including anti-programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. Nivolumab, an anti–PD-1 monoclonal Ab, is an effective treatment of unresectable metastatic melanoma, non–small cell lung cancer, renal cell carcinoma, head and neck cancer, Hodgkin lymphoma, and gastric cancer. These medicines can cause immune-related adverse events (irAEs), including endocrino...

Objective: Assess the effect of bariatric surgery on serum glucagon like peptide-1 (GLP-1) concentration and metabolic and biochemical parameters pre and postoperatively.Methods: This prospective study comprised 50 subjects divided into 3 groups. Group 1: 20 obese subjects with T2DM (BMI >35) that underwent Roux-en-y gastric bypass surgery; Group 2: 20 lean subjects with T2DM and Group 3: 10 lean subjects as healthy controls.Bo...

Introduction: Our objective for the current review was to inquire the thyroid cancer frequency rate within the patients who have had total thyroidectomy procedure for definitive Graves’ disease treatment and to evaluate the contribution of the presence of nodules to malignity rates.Materials and methods: The present study was conducted by scanning the data of 214 patients who were applied total thyroidectomy for permanent Graves disease treatment, r...

Introduction: Alternative to transsphenoidal pituitary surgery (TSS) may be required in Cushing’s disease (CD), as first or second line treatment. 1,ortho-1,para′-dichloro-diphenyl-dichloroethane (o,p′DDD) has a potent anticortisolic action. Its place in CD treatment is not well defined. The aim of this study was to further evaluate the efficacy and tolerance of o,p′DDD in CD.Patients and m...

Selenium (Se) is an essential trace element needed for the biosynthesis of selenoproteins. Biosynthesis of such proteins depends on the selenocysteine incorporation sequence binding protein 2 (SBP2), which represents a key trans-acting factor during the translation process. We recently described children with mutations in SBP2 gene who displayed an abnormal thyroid function test(s) and reduced selenoprotein concentrations. Now we aimed to improve selenoprotein biosynthesis and...

Introduction: Insulin-like growth factor 1 (IGF-1), acting via similar signalling pathways to insulin, enhances glucose uptake and nitric oxide (NO) production. Observational studies suggest a role for (IGF-1) in insulin resistance and cardiovascular disease. To investigate this further we used a murine model with heterozygous knockout of the IGF-1 receptor.Methods: Metabolic tolerance tests were performed in vivo on unanaesthetised mice, heterozy...

Endothelial dysfunction is a key step in the initiation of atherosclerosis, resulting from a decrease in bioavailability of nitric oxide (NO). IGF-1 may play a part in regulation of NO production via the PI3-kinase/Akt/eNOS pathway. We have investigated whether disturbances of this pathway occur in dietary-induced obesity.Obesity was induced in mice fed a high fat diet for 20 weeks (n=12), compared to chow fed controls, with an age-related increas...

Aim: We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).Methods: Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone ...